Double-Layer Hydrogel with Glucose-Activated Two-Stage ROS Regulating Properties for Programmed Diabetic Wound Healing

• DOI: 10.1021/acsami.3c10607
• Publication Date: 2023-10-27T13:40:42Z
• Authors: Min Tan; Jing Zeng; Fu-Zhong Zhang; Ye-Tao Zhang; Hongli Li; Shu-Ting Fan; Jia-Xin Wang; Minglong Yuan; Bang-Jing Li; Sheng Zhang
• Keywords: Gelatin; Glucose oxidase

Slow healing of wounds induces great pain in diabetic patients. However, developing new approaches to promote wound is still one the toughest challenges medical field. Here, we constructed a double-layer hydrogel effectively regulate reactive oxygen species (ROS) on and healing. The inner layer contains glucose oxidase (Gox), ferrocene-modified quaternary ammonium chitosan (Fc-QCs), poly(β-cyclodextrin) (Pβ-CD), which used generate hydroxyl radicals (•OH) for antibacterial early stage collapses gradually. outer composed gelatin dopamine. In later healing, contacts skin, beneficial ROS clearance wound. Antibacterial, scavenging, experiments have shown that possesses two-stage regulating properties programmed conclusion, it will be most potential dressings treating future.