Dual-Targeted Metal Ion Network Hydrogel Scaffold for Promoting the Integrated Repair of Tendon–Bone Interfaces

• DOI: 10.1021/acsami.3c16544
• Publication Date: 2024-01-23T09:17:32Z
• Authors: Jun Ma; Han Yu; Xinyu Zhang; Zhuoming Xu; Hanyin Hu; Jintao Liu; Peng Ren; Xiangjia Kong; Jiayi Chen; Kun Yang; Xinyu Wang; Xiaojun He; Huanhuan Luo; Gang Chen

The tendon-bone interface has a complex gradient structure vital for stress transmission and pressure buffering during movement. However, injury to the tissue, especially tendon cartilage components, often hinders complete restoration of original structure. Here, metal ion network hydrogel scaffold, with capability targeting multitissue, was constructed through photopolymerization LHERHLNNN peptide-modified zeolitic imidazolate framework-8 (LZIF-8) WYRGRL magnesium metal-organic framework (WMg-MOF) within which could facilitate directional migration ions form dynamic gradient, thereby achieving integrated regeneration tissues. LZIF-8 selectively migrated tendon, releasing zinc enhance collagen secretion promoting repair. Simultaneously, WMg-MOF cartilage, induce cell differentiation facilitating regeneration. Infrared spectroscopy confirmed successful peptide modification nano ZIF-8 Mg-MOF. Fluorescence imaging validated that LZIF-8/WMg-MOF had longer retention, indirectly confirming their interface. In summary, this dual-targeted scaffold potential synchronized multitissue at compromised interface, offering favorable prospects its application in reconstruction characterized by