Injectable Nanocomposite Hydrogels with Strong Antibacterial, Osteoinductive, and ROS-Scavenging Capabilities for Periodontitis Treatment

• DOI: 10.1021/acsami.3c16577
• Publication Date: 2024-03-18T12:29:34Z
• Authors: Yue Yu; Ziying You; Xin Li; Feng Lou; Ding Xiong; Ling Ye; Zhenming Wang
• Keywords: Gelatin; Bone tissue

Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, antioxidant properties by facile method periodontitis treatment is still missing. To overcome this issue, we designed an injectable system (GPM) composed of gelatin, Ti3C2Tx MXene nanosheets, poly-l-lysine using simple enzymatic cross-linking technique. Physicochemical characterization demonstrated that the GPM matrix exhibited excellent stability, moderate tissue adhesion ability, good mechanical behavior. The significantly inhibited growth Porphyromonas gingivalis, scavenged reactive oxygen species, attenuated inflammatory responses, enhanced regeneration. Intriguingly, arrangement junctional epithelium, alveolar volume, height in GPM-treated periodontal disease group recovered healthy group. Therefore, our functions may serve as scaffold periodontitis.