Multifunctional 58S Bioactive Glass/Silver/Cerium Oxide-Based Biocomposites with Effective Antibacterial, Cytocompatibility, and Mechanical Properties

• DOI: 10.1021/acsami.3c17400
• Publication Date: 2024-04-08T18:04:14Z
• Authors: Indrajeet Singh; Kaushal Shakya; Pankaj Gupta; Pooja Rani; Ing Kong; Vivek Verma; Kantesh Balani
• Keywords: Cerium oxide

58S bioactive glass (BG) has effective biocompatibility and bioresorbable properties for bone tissue engineering; however, it limitations regarding antibacterial, antioxidant, mechanical properties. Therefore, we have developed BGAC biocomposites by reinforcing BG with silver ceria nanoparticles, which showed bactericidal forming inhibited zones of 2.13 mm (against Escherichia coli) 1.96 Staphylococcus aureus; evidenced disc diffusion assay) an increment in the antioxidant 39.9%. Moreover, elastic modulus, hardness, fracture toughness were observed to be increased ∼84.7% (∼51.9 GPa), ∼54.5% (∼3.4 ∼160% (∼1.3 MPam1/2), whereas specific wear rate was decreased ∼55.2% (∼1.9 × 10-11 m3/Nm). X-ray diffraction, high-resolution transmission electron microscopy, field emission scanning microscopy confirmed fabrication uniform distribution nanomaterials matrix. The addition nanoparticles matrix (in BGA) composite strengthening damaging cytoplasmic membrane bacterial cells. nanoceria (BGC) 44.5% (as 2,2-diphenyl-1-picrylhydrazyl assay). resazurin reduction assay MTT cytocompatibility against mouse embryonic fibroblast cells (NIH3T3) marrow stromal Overall, resulted comparable those cancellous bone, its antibacterial make a good candidate healing.