Branched-Chain-Induced Host–Guest Assembly in Covalent-Organic Frameworks for Efficient Separation of No-Carrier-Added 177Lu

• DOI: 10.1021/acsami.3c19054
• Publication Date: 2024-02-12T20:39:13Z
• Authors: Haiyue Peng; Feize Li; Yilin Qin; Shilong Shi; Guoquan Ma; Xisheng Fan; Yang Li; Lijian Ma; Ning Liu
• Keywords: Chain (unit); Separation (statistics)

No-carrier-added (NCA) 177Lu is one of the most interesting nuclides for endoradiotherapy. With dramatically rapid development radiopharmaceutical and nuclear medicine, there a sharp increase in radionuclide supply NCA 177Lu, which has formed great challenge to current radiochemical separation constituted on classical materials. Hence, it vital importance design prepare new functional materials able recovering from an irradiated target with excellent efficacy. In this work, we proposed apply noncovalent interactions regulate porous properties covalent organic frameworks (COFs) by tuning branched chain, rendering related hosts different encapsulation abilities toward flexible guest, 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (P507). More interestingly, found that interaction effect host–guest complexes, can achieve efficient high recovery (95.97%). A systematic mechanism combined experimental theoretical investigations confirmed between COFs P507 play preeminent role adjusting macroscopic complexes. This work not only uncovers affect basic bonded but also provides strategy preparation other moieties specific functionalities.