Pyrene Derivative Incorporated Ni MOF as an Enzyme Mimic for Noninvasive Salivary Glucose Detection Toward Diagnosis of Diabetes Mellitus

• DOI: 10.1021/acsami.3c19431
• Publication Date: 2024-04-02T04:17:19Z
• Authors: Mallikarjuna Swam...; Guru Prasad Kuppu...; Sheethal Sasi; Surya Velappa Jay...; Venkatramaiah Nut...; Shanmugam Senthil...; Yuvaraj Sivalingam

Herein, we demonstrate the detection of glucose in a noninvasive and nonenzymatic manner by utilizing an extended gate field-effect transistor (EGFET) based on organic molecule pyrene phosphonic acid (PyP4OH8) incorporated nickel metal–organic framework (NiOM-MOF). The prepared electrode responds selectively to instead sucrose, fructose, maltose, ascorbic acid, uric 1× phosphate buffer saline solution. Also, scanning Kelvin probe system, sensing electrode's work function (Φ) is measured validate glucose-sensing mechanism. sensitivity, range, response time, limit detection, quantification are determined be 24.5 μA mM–1 cm–2, 20 μM 10 mM, less than 5 s, 2.73 μM, 8.27 respectively. Most interestingly, developed follows Michaelis–Menten kinetics, calculated rate constant (km) 0.07 mM indicates higher affinity NiOM-MOF toward glucose. real-time analysis has revealed that sensitive detect real human saliva, it can alternative device for Overall, outcomes EGFET studies electrodes well-suited expeditious levels saliva.