Effects of the Biomimetic Microstructure in Electrospun Fiber Sutures and Mechanical Tension on Tissue Repair

• DOI: 10.1021/acsami.4c01478
• Publication Date: 2024-05-24T19:37:06Z
• Authors: Jie Dang; Shifen Huang; Shengmei Li; Jingyao Liu; Zibo Chen; Liu Wang; Jie Wang; Hao Chen; Shanshan Xu
• Keywords: Microfiber; Tissue Repair

Electrospun microfibers, designed to emulate the extracellular matrix (ECM), play a crucial role in regulating cellular microenvironment for tissue repair. Understanding their mechanical influence and inherent biological interactions at ECM interface, however, remains complex challenge. This study delves into of cues repair by fabricating Col/PLCL microfibers with varying chemical compositions alignments that mimic structure ECM. Furthermore, we optimized these create Col/PLCL@PDO aligned suture, specific emphasis on tension The result reveals within fibers identical composition, fibroblast proliferation is more pronounced than unaligned ones. Moreover, cells exhibit an increased aspect ratio. In vivo experiments demonstrated as certain level, cell augmented, assumed elongated morphologies distinct protrusions, there was elevated secretion collagen III facilitating soft research illuminates structural dynamics electrospun fiber scaffolds; it will provide insights advancement precise controllable engineering materials.