Targeted Delivery of Quinoxaline-Based Semiconducting Polymers for Tumor Photothermal Therapy

• DOI: 10.1021/acsami.4c05668
• Publication Date: 2024-07-12T17:43:24Z
• Authors: Peiling Chen; Xiaoying Wang; Chunguang Zhu; Ting Guo; Chunxiao Wang; Lei Ying
• Keywords: Quinoxaline; Cancer Therapy

Photothermal therapy (PTT) holds great potential in the field of cancer treatment due to its high specificity and low invasiveness. However, conversion efficiency, inadequate tumor accumulation, limited cellular uptake continue impede PTT effectiveness treating tumors. The present study focuses on utilization quinoxaline nanoparticles develop an organic semiconducting photothermal agent (PAQI-BDTT) for therapy. To achieve this, PAQI-BDTT was encapsulated within liposomes modified with cyclic Arg-Gly-Asp (cRGD) peptide targeting tumors (named T-BDTT-Lipo). Notably, T-BDTT-Lipo demonstrated a positive efficiency 74% when exposed 808 nm laser, along NIR-II fluorescence imaging capabilities. efficacy tissue accumulation precise malignant cells has been confirmed through both vitro vivo experiments guided by imaging. Under single dose light irradiation, generated local intracellular hyperthermia at site. elevated temperature additionally exerted significant inhibitory effect growth recurrence, thereby extending survival duration mice harboring therapeutic nanosystem (T-BDTT-Lipo) proposed this work demonstrates enormous agents therapy, laying foundation next clinical application.