Optimized Bionic Drug-Delivery-Inducing Immunogenic Cell Death and cGAS-STING Pathway Activation for Enhanced Photodynamic-Chemotherapy-Driven Immunotherapy in Prostate Cancer

• DOI: 10.1021/acsami.4c07072
• Publication Date: 2024-08-09T11:35:06Z
• Authors: Chunchen Wu; Dexiang Feng; Hongbo Xu; Zhangxin He; Jianquan Hou
• Keywords: Immunogenic cell death; Sting

Prostate cancer presents as a challenging disease, it is often characterized an immunologically "cold" tumor, leading to suboptimal outcomes with current immunotherapeutic approaches in clinical settings. Photodynamic therapy (PDT) harnesses reactive oxygen species generated by photosensitizers (PSs) disrupt the intracellular redox equilibrium. This process induces DNA damage both mitochondria and nucleus, activating of immunogenic cell death (ICD) cGAS-STING pathway. Ultimately, this cascade events leads initiation antitumor immune responses. Nevertheless, existing PSs face challenges, including tumor targeting, aggregation-induced quenching, insufficient levels regions. To end, versatile bionic nanoplatform has been designed for simultaneous delivery emission PS TPAQ-Py-PF