Engineering Surface-Adaptive Metal–Organic Framework Armor to Promote Infected Wound Healing

• DOI: 10.1021/acsami.4c20219
• Publication Date: 2024-12-18T01:56:52Z
• Authors: Jia-Cheng Lv; Xue Yang; Zi-Li Zheng; Zhi-Guo Wang; Rui Hong; Yao Liu; En Luo; Ju-Xiang Gou; Lingli Li; Bo Yuan; Jia-Zhuang Xu; Zhong-Ming Li
• Keywords: Superhydrophilicity; Biocompatibility; Armour

Metal–organic frameworks (MOFs) hold enormous promise for treating bacterial infections to circumvent the threat of antibiotic resistance. However, positioning MOFs on wound dressings is hindered and remains a significant challenge. Herein, facile heterointerfacial engineering strategy was developed tailor "MOF armor" that adaptively weaponized poly(ε-caprolactone) electrospun dressing with excellent bacteria-killing efficacy. Hydrophilic epitaxial crystallization enhance interfacial wettability key induce uniform seeding Cu2+ thus generate compact MOF layer dressing. The universality proposed demonstrated by construction different kinds (HKUST-1, ZIF-8, ZIF-67) variously shaped substrates (nanofibers, pellets, plates, 3D-printed porous scaffolds). By optimizing loading, Cu-MOF armor exhibited sustained ion release behavior, strong antibacterial activity, good biocompatibility. In vivo rat model revealed significantly promoted infected healing inhibiting inflammatory factors, promoting collagen deposition, angiogenesis. This unique provides an appealing effective solution designing fabricating advanced dressings.