Structural Optimization of 3D-Printed Porous Titanium Implants Promotes Bone Regeneration for Enhanced Biological Fixation

• DOI: 10.1021/acsami.4c22401
• Publication Date: 2025-03-11T13:28:51Z
• Authors: Haoyuan Lei; Zhigang Zhou; Jia Liu; Hongfu Cao; Lina Wu; Ping Song; Bangcheng Yang; Wenzheng Zhou; Yongsheng Liu; Qingquan Kong; Yujiang Fan; Changchun Zhou
• Keywords: 3d printed; Biocompatible material

Structural defects and biological inertness significantly impair the integration of titanium alloy implants bone tissues. In spinal internal fixation, issue pedicle screw loosening or fracture caused by poor urgently needs solving. this study, we utilized 3D printing technology to custom fabricate a structurally optimized porous with aim enhancing regeneration at defect site, thereby fixation implant in vivo. Results showed that unit has superior mechanical properties actively promotes cell adhesion growth surface interface. The based on structure immediate bonding strength bending resistance comparable clinical products provides an optimal spatial for newly regenerated ingrowth integration. Alkali-thermal activation constructed bioactive sodium titanate coating surface, which promoted proliferation, adhesion, osteogenic differentiation BMSCs. This further enhances performance interface, highlighting advantages optimization. beagle vertebrae, surrounding inward bone, strengthening osseointegration interface inside, thus synergistically fixation. study pioneers introduction into through structural optimization, innovative strategy development improves potential value advancing utilization 3D-printed orthopedic implants.