Shish-Kebab-Structured Poly(ε-Caprolactone) Nanofibers Hierarchically Decorated with Chitosan–Poly(ε-Caprolactone) Copolymers for Bone Tissue Engineering

• DOI: 10.1021/acsami.5b00900
• Publication Date: 2015-03-11T19:08:54Z
• Authors: Xin Jing; Hao-Yang Mi; Xin-Chao Wang; Xiang-Fang Peng; Lih-Sheng Turng
• Keywords: Caprolactone; Electrospinning; Biocompatibility; Polycaprolactone

In this work, scaffolds with a shish-kebab (SK) structure formed by poly(ε-caprolactone) (PCL) nanofibers and chitosan–PCL (CS–PCL) copolymers were prepared via electrospinning subsequent crystallization for bone tissue engineering applications. The aim of study was to introduce nanosized topography the high biocompatibility chitosan onto PCL enhance cell affinity scaffolds. CS–PCL various ratios synthesized, then spontaneously crystallized as kebabs electrospun fibers, which acted shishes. Scanning electron microscopy (SEM) results demonstrated that copolymer ratio 8.8 could hierarchically decorate well–shaped on nanofiber surface. Water contact angle tests biomimetic activity experiments revealed (PCL–SK(CS–PCL8.8)) showed enhanced hydrophilicity mineralization ability compared smooth PCL–SK(PCL) Osteoblast-like MG63 cells cultured PCL–SK(CS–PCL8.8) optimizing attachment, viability, metabolic activity, demonstrating kind scaffold has potential applications in engineering.