Chlorin e6 Conjugated Poly(dopamine) Nanospheres as PDT/PTT Dual-Modal Therapeutic Agents for Enhanced Cancer Therapy

• DOI: 10.1021/acsami.5b01027
• Publication Date: 2015-04-03T09:56:20Z
• Authors: Da Zhang; Ming Wu; Yongyi Zeng; Lingjie Wu; Qingtang Wang; Xiao Han; Xiaolong Liu; Jingfeng Liu
• Keywords: Phototoxicity

Photodynamic therapy (PDT), using a combination of chemical photosensitizers (PS) and light, has been successfully applied as noninvasive therapeutic procedure to treat tumors by inducing apoptosis or necrosis cancer cells. However, most current clinically used PS have suffered from the instability in physiological conditions which lead low photodynamic efficacy. Herein, highly biocompatible poly(dopamine) (PDA) nanoparticle conjugated with Chlorin e6 (referenced PDA-Ce6 nanosphere) was designed nanotherapeutic agent achieve simultaneous photodynamic/photothermal (PDT/PTT). Compared free Ce6, nanosphere exhibited significantly higher PDT efficacy against tumor cells, because enhanced cellular uptake subsequently greater reactive oxygen species (ROS) production upon laser irradiation at 670 nm. Meanwhile, could be also photoabsorbing for PTT, excellent photothermal conversion ability PDA under 808 Moreover, our prepared had extremely dark toxicity, while phototoxicity nm, both vitro vivo, compared any single alone. Therefore, very promising dual-modal phototherapeutic future clinical applications.