Killing Dental Pathogens Using Antibacterial Graphene Oxide

• DOI: 10.1021/acsami.5b01069
• Publication Date: 2015-02-23T19:30:37Z
• Authors: Jianliang He; Xiaodan Zhu; Zhengnan Qi; Chang Wang; Xiaojun Mao; Cailian Zhu; Zhiyan He; Mingyu Li; Zisheng Tang
• Keywords: Fusobacterium nucleatum

Dental caries and periodontal diseases have a close relationship with microbes such as Streptococcus mutans, Porphyromonas gingivalis Fusobacterium nucleatum. Graphene oxide (GO), the derivative of graphene, plays an important role in many areas including biology medicine. In particular, it has been known promising antimicrobial nanomaterial. this study, we focused on property GO against dental pathogens. With utilization 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduced test, colony forming units (CFU) counting, growth curve observation, live/dead fluorescent staining, confocal laser scanning microscopy (CLSM), found nanosheets were highly effective inhibiting Transmission electron (TEM) images revealed that cell wall membrane bacteria lost their integrity intracellular contents leaked out after they treated by GO. Therefore, would be antibacterial material pathogens potential applications care therapy are promising.