Mn2+-Doped Prussian Blue Nanocubes for Bimodal Imaging and Photothermal Therapy with Enhanced Performance

• DOI: 10.1021/acsami.5b02510
• Publication Date: 2015-05-12T12:36:32Z
• Authors: Wenwen Zhu; Kai Liu; Xiaoqi Sun; Xin Wang; Yonggang Li; Liang Cheng; Zhuang Liu
• Keywords: Manganese; Mice, Inbred BALB C; Photosensitizing Agents; Contrast Media; Metal Nanoparticles; Neoplasms, Experimental; Magnetic Resonance Imaging; 01 natural sciences; Theranostic Nanomedicine; 0104 chemical sciences; 3. Good health; Mice; Treatment Outcome; Nanocapsules; Photochemotherapy; Cell Line, Tumor; Animals; Ferrocyanides

Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications in magnetic resonance (MR) imaging as well as photothermal cancer treatment. In this work, we take a closer look at the imaging and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped PB nanocubes exhibit increased longitudinal relaxivity along with enhanced optical absorption red-shifted to the near-infrared (NIR) region. Those properties make PB:Mn nanocubes with appropriate surface coatings rather attractive agents for biomedical imaging and cancer therapy, which have been successfully demonstrated in our in vivo experiments for effectively tumor ablation.