An Oxidative Stress Nanoamplifier with Efficient Non-Fenton-Type Hydroxyl Radical Generation and Sulfur Dioxide Release for Synergistic Treatment of Tumor

• DOI: 10.1021/acsami.5c01310
• Publication Date: 2025-03-08T14:00:06Z
• Authors: Shasha Zhao; Zhonghuan Qu; Likai Wang; Peng Gu; Juan Mou; Shiping Yang; Huixia Wu
• Keywords: Hydroxyl radical

Overcoming tumor antioxidant defenses remains a critical challenge for reactive-oxygen-species-mediated therapies. To address this problem, herein, theranostic nanomedicine designated as CCM@MIB has been elaborately constructed. Homologous cancer cell membrane (CCM) camouflage significantly enhances the selective accumulation of at sites. In response to microenvironment (TME), controllably releases Mn ions and sulfur dioxide (SO2) molecules. The released catalyze self-oxidation isoniazid generate highly toxic •OH, while SO2 produced by benzothiazole sulfinate effectively disrupts defense systems. catalase-like activity endowed increased intracellular •O2– level induced further promote •OH production. Therefore, such an intellectual combination non-Fenton-type catalytic therapy gas amplifies oxidative stress efficiently suppresses growth. Additionally, TME-activated magnetic resonance imaging contrast performance is beneficial guiding antitumor treatment. This considerate strategy designed in our work provides ingenious paradigm development efficient