Remote Control of Gold–Iron Nanowires Using Low-Frequency 1 Hz Magneto-Mechanical Therapy and Cesium 137 0.662 MeV Radiotherapy for Treatment of Glioblastoma Multiforme

• DOI: 10.1021/acsami.5c05004
• Publication Date: 2025-05-28T12:39:39Z
• Authors: Jonathan Taylor; George Greaves; Chris Clement Phi...; Matthew Williams; Mary P. Ryan; Alexandra E. Porter
• Keywords: Caesium; Magneto

Glioblastoma (GBM) is an extremely infiltrative brain cancer that impossible to fully remove surgically and almost always recurs at the borders of resection cavity. There increasing focus on inducing cell death using magneto-mechanical therapy (MMT), which involves energy conversion external low-frequency magnetic field into mechanical forces nanoparticles. Here, we combined MMT with enhanced radiotherapy (RT)─the standard care treatment for GBM─to increase efficiency gold-iron nanowires (AuFe NWs). The iron component mechanically rotates, cellular damage, gold scatters X-rays due its high atomic number, enhancing local RT dose. We show reproducible synthesis AuFe NWs different ratios gold:iron can be achieved a hard-template electrochemical method, controlling composition by tuning deposition current. Ratios best-performing percentages were selected computational modeling predict frequency should applied in vitro GBM line. In testing, metabolism assay, optimal ratio, demonstrated applying alongside resulted synergistic effect, reducing viability significantly ∼60% (as compared 30% reduction RT, with/without NWs), 20% (with increased efficacy post-MMT, was attributed higher association cells following application membrane damage.