Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery

• DOI: 10.1021/acsami.6b00555
• Publication Date: 2016-03-01T00:41:46Z
• Authors: Ning Lin; Annabelle Gèze; Denis Wouessidjewe; Jin Huang; Alain Dufresne
• Keywords: Cationic polymerization; Biocompatibility; Biocompatible material

A biocompatible hydrogel with a double-membrane structure is developed from cationic cellulose nanocrystals (CNC) and anionic alginate. The architecture of the involves an external membrane composed neat alginate, internal composite consolidates by electrostatic interactions between CNC thickness outer layer can be regulated adsorption duration shape inner directly determine morphology dimensions (microsphere, capsule, filmlike shapes). Two drugs are introduced into different membranes hydrogel, which will ensure complexing codelivery varied release behaviors two (rapid drug prolonged hydrogel). containing chemically modified (CCNC) in provide sustained ascribed to "nano-obstruction effect" "nanolocking induced presence CCNC components hydrogels. Derived natural polysaccharides (cellulose alginate), novel material this study realize first quick one successively slow another drug, expected achieve synergistic effects or potentially solution resistance biomedical application.