Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy

• DOI: 10.1021/acsami.6b02416
• Publication Date: 2016-05-13T14:08:50Z
• Authors: Ruiyun Zhang; Ruirui Xing; Tifeng Jiao; Kai Ma; Chengjun Chen; Guanghui Ma; Xuehai Yan
• Keywords: Male; Drug Carriers; Mice, Inbred BALB C; Antineoplastic Agents; 01 natural sciences; Theranostic Nanomedicine; 0104 chemical sciences; 3. Good health; Mice; Doxorubicin; Cell Line, Tumor; MCF-7 Cells; Animals; Humans; Nanoparticles; Female

There are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including recurrence, complex multistep preparations formulation. To address these issues, herein a simple green approach based on self-assembly agents photosensitizer (chlorine e6, Ce6) chemotherapeutic agent (doxorubicin, DOX) was developed to prepare carrier-free nanoparticles (NPs) with ability inhibit recurrence. The designed NPs were formed by Ce6 DOX associated electrostatic, π-π stacking hydrophobic interactions. They have relatively uniform size average 70 nm, surface charge -20 mV high drug encapsulation efficiency, which benefits favorable accumulation drugs at region through potential enhanced permeability retention (EPR) effect as compared their counterpart free solution. In addition, they could eradiate tumors without recurrence in synergistic way following one cycle. Furthermore, safe any activation inflammation or immune response separated organs. Taken together, rationale pure nanodrugs via might open an alternative avenue give inspiration fabricate new for theranostics, especially two small molecular antitumor aim combinational therapy way.