Structure–Antibacterial Activity Relationships of Imidazolium-Type Ionic Liquid Monomers, Poly(ionic liquids) and Poly(ionic liquid) Membranes: Effect of Alkyl Chain Length and Cations

• DOI: 10.1021/acsami.6b03391
• Publication Date: 2016-05-04T15:21:40Z
• Authors: Zhiqiang Zheng; Qiming Xu; Jiangna Guo; Jing Qin; Hailei Mao; Bin Wang; Feng Yan
• Keywords: Staphylococcus aureus; Structure-Activity Relationship; Cations; Escherichia coli; Ionic Liquids; Membranes, Artificial; 02 engineering and technology; 0210 nano-technology; Anti-Bacterial Agents; 3. Good health

The structure–antibacterial activity relationship between the small molecular compounds and polymers are still elusive. Here, imidazolium-type ionic liquid (IL) monomers their corresponding poly(ionic liquids) (PILs) liquid) membranes were synthesized. effect of chemical structure, including carbon chain length substitution at N3 position charge density cations (mono- or bis-imidazolium) on antimicrobial activities against both Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) was investigated by determination minimum inhibitory concentration (MIC). antibacterial ILs PILs improved with increase alkyl higher (bis-cations) imidazolium cations. Moreover, exhibited lower MIC values relative to IL monomers. However, PIL showed no correlation those analogous molecule PILs, which increased while decreasing length. results indicated that property studies molecules homopolymers may not provide a solid basis for evaluating in polymer membranes.