Copolymer Brushes with Temperature-Triggered, Reversibly Switchable Bactericidal and Antifouling Properties for Biomaterial Surfaces

• DOI: 10.1021/acsami.6b08893
• Publication Date: 2016-09-23T13:58:40Z
• Authors: Bailiang Wang; Qingwen Xu; Zi Ye; Huihua Liu; Quankui Lin; Kaihui Nan; Yunzhen Li; Yi Wang; Lei Qi; Hao Chen
• Keywords: Biofouling; Biomaterial; Surface Modification

The adherence of bacteria and the formation biofilm on implants is a serious problem that often leads to implant failure. A series antimicrobial coatings have been constructed resist bacterial or kill through contact with release antibacterial agents. accumulation dead facilitates further contamination development. Herein, we designed novel, reversibly switchable bactericidal antifouling surface surface-initiated reversible addition–fragmentation chain transfer (RAFT) polymerization combine thermally responsive N-isopropylacrylamide (NIPAAm) quaternary ammonium salts (2-(dimethylamino)-ethyl methacrylate (DMAEMA+)). Measurements spectroscopic ellipsometry water angle X-ray photoelectron spectroscopy were used examine process functionalization. temperature-responsive P(DMAEMA+-co-NIPAAm) copolymer coating can switch by phase transition between hydrophobic capturing at high temperatures relatively hydrophilic lower temperatures. PDMAEMA+ displayed efficiency against both Escherichia coli Staphylococcus aureus. functionalized could efficiently prevent bovine serum albumin adsorption had good biocompatibility human lens epithelial cells.