Zeolite Nanoparticles Inhibit Aβ–Fibrinogen Interaction and Formation of a Consequent Abnormal Structural Clot

• DOI: 10.1021/acsami.6b10941
• Publication Date: 2016-10-21T11:58:50Z
• Authors: Hossein Derakhsha...; Mohammad Javad Ha...; Ebrahim Barzegari; Alireza Lotfabadi; Maryam Ferdousi; Ali Akbar Saboury; Eng Poh Ng; Mohammad Raoufi; Hussein Awala; Svetlana Mintova; Rassoul Dinarvand; Morteza Mahmoudi
• Keywords: 0301 basic medicine; 03 medical and health sciences; Amyloid beta-Peptides; Alzheimer Disease; [CHIM] Chemical Sciences; Zeolites; [CHIM]Chemical Sciences; Fibrinogen; Humans; Metal Nanoparticles; 3. Good health

EMT-type zeolite nanoparticles (EMT NPs) with particle size of 10-20 nm and external surface area 200 m2/g have shown high selective affinity toward plasma protein (fibrinogen). Besides, the EMT NPs demonstrated no adverse effect on blood coagulation hemostasis. Therefore, it was envisioned that could inhibit possible β-amyloid (Aβ)-fibrinogen interactions result in formation structurally abnormal clots, which are resistant to lysis, cerebral vessels patients Alzheimer disease (AD). To evaluate this hypothesis, clot degradation Aβ-fibrinogen presence absence were assessed. The results clearly showed delay dissolution significantly reduced NPs. By corona, a negligible reduction their inhibitory strength. Docking small molecules (Aβ-fibrinogen) introduced novel potential candidate. similar effects binding fibrinogen both Aβ(25-35) and/or Aβ(1-42). This indicates strength these is independent Aβ sequence, suggested adsorb specifically obstruct sites. can be safe effective inhibitors preventing interaction consequent cognitive damage.