Engineering Phototheranostic Nanoscale Metal–Organic Frameworks for Multimodal Imaging-Guided Cancer Therapy

• DOI: 10.1021/acsami.6b11579
• Publication Date: 2016-12-29T13:11:26Z
• Authors: Wen Cai; Haiyan Gao; Chengchao Chu; Xiaoyong Wang; Junqing Wang; Pengfei Zhang; Gan Lin; Wengang Li; Gang Liu; Xiaoyuan Chen
• Keywords: Indocyanine Green

Many photoresponsive dyes have been utilized as imaging and photodynamic/photothermal therapy agents. Indocyanine green (ICG) is the only near-infrared region (NIR) organic dye for clinical applications approved by United States Food Drug Administration; however, application of ICG limited its poor aqueous solubility, low cancer specificity, sensitivity in theranostics. To overcome these issues, a multifunctional nanoplatform based on hyaluronic acid (HA) ICG-engineered metal-organic framework MIL-100(Fe) nanoparticles (MOF@HA@ICG NPs) was successfully developed imaging-guided, anticancer photothermal (PTT). The synthesized NPs showed high loading content (40%), strong NIR absorbance, photostability. vitro vivo that MOF@HA@ICG exhibited greater cellular uptake CD44-positive MCF-7 cells enhanced tumor accumulation xenograft tumors due to their targeting capability, compared MOF@ICG (non-HA-targeted) free ICG. toxicity PTT treatments demonstrated could effectively inhibit growth cells/xenograft tumors. These results suggest be served new promising theranostic improved through cancer-specific image-guided drug delivery.