Relighting Photosensitizers by Synergistic Integration of Albumin and Perfluorocarbon for Enhanced Photodynamic Therapy

• DOI: 10.1021/acsami.6b14885
• Publication Date: 2017-01-09T10:18:56Z
• Authors: Hao Ren; Jiaqi Liu; Fenhong Su; Sizhan Ge; Ahu Yuan; Weimin Dai; Jinhui Wu; Yiqiao Hu
• Keywords: Fluorocarbons; Mice; Photosensitizing Agents; Photochemotherapy; Singlet Oxygen; Albumins; Animals; Humans; 02 engineering and technology; 0210 nano-technology; 01 natural sciences; 0104 chemical sciences; 3. Good health

Photodynamic therapy (PDT) is hampered by poor water solubility and skin phototoxicity of photosensitizers (PSs). Incorporation PSs into nanocarrier (Nano-PDT) has been designed to overcome these problems. However, self-quenching highly condensed in Nano-PDT significantly reduced singlet oxygen (1O2) generation, resulting unsatisfactory PDT efficacy. Here, we developed a novel tripleffect Nano-PDT, which special core-shell nanostructure synergistic integration perfluorotributylamine (PFTBA) human serum albumin (HSA) improve PDT. It three mechanisms relight quenched PSs, thereby generating more 1O2. First, uniformly dispersed the shell, preventing caused π-π stacking. Second, HSA as extends triplet-state lifetimes increasing amount Third, PFTBA core dissolves protects1 O2 extend duration time action Compared with PS-encapsulated can be effectively overcome. The fluorescence 1O2 generation PS are increased approximately 100-fold 15-fold, respectively. After intravenous injection tumor-bearing mice, tumor growth inhibited, while almost no effect. may guide improvement existing clinical future design.