Mesoporous Metal–Organic Framework with Well-Defined Cruciate Flower-Like Morphology for Enzyme Immobilization

• DOI: 10.1021/acsami.7b00512
• Publication Date: 2017-03-10T15:13:31Z
• Authors: Jiandong Cui; Yuxiao Feng; Tao Lin; Zhilei Tan; Cheng Zhong; Shiru Jia
• Keywords: Dodecahedron; Imidazolate; Morphology

Metal-organic frameworks (MOFs) have recently emerged as a promising candidates for the immobilization of enzymes due to their diversified structures and porosity. However, lack good size morphological control over as-prepared MOFs has limited practical applications in some cases. Herein, instead zeolitic imidazolate framework-8 (ZIF-8) with standard rhombic dodecahedral morphology, we successfully synthesize novel mesoporous catalase@ZIF composite cruciate flower-like morphology by embedding catalase molecules into uniformly sized ZIF crystals. With extraordinarily large mesopore high protein loading capacity, composites exhibit 400% higher activity than that conventional show reusability morphology. More importantly, demonstrate first time biomacromolecules (proteins) can not directly regulate crystal size, crystallinity ZIF-8. Moreover, primary dependence on concentrations 2-methylimidazole Zn2+ ions, be controlled adjusting ions while keeping concentration 2-methylimidazole.