Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemophotothermal Synergistic Cancer Therapy

• DOI: 10.1021/acsami.7b02307
• Publication Date: 2017-05-23T08:13:10Z
• Authors: Xiaoyu Xu; Ziyuan Huang; Zeqian Huang; Xuefei Zhang; Siyu He; Xiaoqi Sun; Yifeng Shen; Mina Yan; Chunshun Zhao
• Keywords: Cancer Therapy

In this study, gold nanorods (GNRs) were incorporated into the hydrogel networks formed by copolymerization of N-isopropylacrylamide (NIPAm) and methacrylated poly-β-cyclodextrin (MPCD)-based macromer to fabricate an injectable near-infrared (NIR)/pH-responsive poly(NIPAm-co-MPCD)/GNRs nanocomposite hydrogel, which could serve as a long-acting implant for chemophotothermal synergistic cancer therapy. The showed superior mechanical swelling properties, gelation characteristics, excellent NIR-responsive property. A hydrophobic acid-labile adamantane-modified doxorubicin (AD-DOX) prodrug was loaded efficiently host-guest interaction. exhibited manner sustained drug release sustain slow steady DOX more than 1 month. pH-responsive from observed owing cleavage hydrazone bond between adamantyl group in acidic environment. NIR irradiation accelerate networks, controlled collapse induced photothermal effect GNRs. vitro cytotoxicity test demonstrated biocompatibility hydrogel. Moreover, situ-forming promising tissue mouse model study. vivo antitumor capacity therapy with reduced adverse effects prolonged retention tumor region efficient effect. Therefore, NIR/pH-responsive great potential long term delivery platform