Near-Infrared Light Responsive Folate Targeted Gold Nanorods for Combined Photothermal-Chemotherapy of Osteosarcoma

• DOI: 10.1021/acsami.7b03711
• Publication Date: 2017-04-06T17:58:03Z
• Authors: Anna Li Volsi; Cinzia Scialabba; Valeria Vetri; Gennara Cavallaro; Mariano Licciardi; Gaetano Giammona
• Keywords: Nanorod; Zeta potential

Folate-targeted gold nanorods (GNRs) are proposed as selective theranostic agents for osteosarcoma treatment. An amphiphilic polysaccharide based graft-copolymer (INU-LA-PEG-FA) and an amino derivative of the α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide functionalized with folic acid (PHEA-EDA-FA), have been synthesized to act coating GNRs. The obtained polymer-coated GNRs were characterized in terms size, shape, zeta potential, chemical composition, aqueous stability. They protected anticancer drug nutlin-3 able deliver it efficiently different physiological media. ability systems selectively kill tumor cells was tested on U2OS cancer expressing high levels FRs compared human bronchial epithelial (16HBE) dermal fibroblasts (HDFa). property nanosystems controlling release upon NIR laser irradiation acting excellent hyperthermia agent well Two Photon Luminescence imaging contrast demonstrated. folate-targeted also chemoterapeutic thermoablation efficacy tridimensional (3-D) models.