Facile and Versatile Strategy for Construction of Anti-Inflammatory and Antibacterial Surfaces with Polydopamine-Mediated Liposomes Releasing Dexamethasone and Minocycline for Potential Implant Applications

• DOI: 10.1021/acsami.7b06295
• Publication Date: 2017-11-15T15:54:57Z
• Authors: Xiao Xu; Lixin Wang; Zuyuan Luo; Yaofeng Ni; Haitao Sun; Xiang Gao; Yongliang Li; Siqi Zhang; Yan Li; Shicheng Wei
• Keywords: Biocompatibility; Quartz Crystal Microbalance; Surface Modification; Proinflammatory cytokine

Reducing early nonbacterial inflammation induced by implanted materials and infection resulting from bacterial contamination around the implant-abutment interface could greatly decrease implant failure rates, which would be of clinical significance. In this work, we presented a facile versatile strategy for construction anti-inflammatory antibacterial surfaces. Briefly, surfaces polystyrene culture plates were first coated with polydopamine then decorated dexamethasone plus minocycline-loaded liposomes (Dex/Mino liposomes), was validated contact angle goniometry, quartz crystal microbalance, fluorescence microscopy. Dex/Mino dispersed on functional drug release kinetics exhibited sustained minocycline. Our results demonstrated that liposome-modified had good biocompatibility. Additionally, liposomal reduced proinflammatory mediator expression (particularly IL-6 TNF-α) in lipopolysaccharide-stimulated human gingival fibroblasts mesenchymal stem cells. Moreover, minocycline prevented adhesion proliferation Porphyromonas gingivalis (Gram-negative bacteria) Streptococcus mutans (Gram-positive bacteria). These findings demonstrate an surface developed, using dopamine as medium combining delivery device, has potential use to reduce rates. Accordingly, modification useful biofunctionalization materials.