Hyperbranched Phosphorescent Conjugated Polymer Dots with Iridium(III) Complex as the Core for Hypoxia Imaging and Photodynamic Therapy

• DOI: 10.1021/acsami.7b09721
• Publication Date: 2017-08-10T15:38:02Z
• Authors: Zhiying Feng; Peng Tao; Liang Zou; Pengli Gao; Yuan Liu; Xing Liu; Hua Wang; Shujuan Liu; Qingchen Dong; Jie Li; Bingshe Xu; Wei Huang; Wai-Yeung Wong; Qiang Zhao
• Keywords: Polyfluorene; Fluorescence-lifetime imaging microscopy; Tumor Hypoxia

Real-time monitoring of the contents molecular oxygen (O2) in tumor cells is great significance early diagnosis cancer. At same time, photodynamic therapy (PDT) could be realized by highly toxic singlet (1O2) generated situ during O2 sensing, making it one most promising methods for cancer therapy. Herein, iridium(III) complex cored hyperbranched phosphorescent conjugated polymer dots with negative charges hypoxia imaging and efficient PDT was rationally designed synthesized. The incomplete energy transfer between polyfluorene complexes ratiometric sensing accurate measurements. Furthermore, O2-dependent emission lifetimes are also used photoluminescence lifetime time-gated luminescence eliminating autofluorescence remarkably to enhance signal-to-noise ratio imaging. Notably, generate 1O2 effectively aqueous solution, image-guided successfully investigated detail confocal laser scanning microscope. To best our knowledge, this represents first example both simultaneously.