Nano Air Seeds Trapped in Mesoporous Janus Nanoparticles Facilitate Cavitation and Enhance Ultrasound Imaging

• DOI: 10.1021/acsami.7b11007
• Publication Date: 2017-09-18T16:24:51Z
• Authors: Konstantin Tamarov; Andrey Sviridov; Wujun Xu; Markus Malo; Valery Andreev; Victor Timoshenko; Vesa-Pekka Lehto
• Keywords: Nanopore

The current contrast agents utilized in ultrasound (US) imaging are based on microbubbles which suffer from a short lifetime systemic circulation. present study introduces new type of agent for US bioresorbable Janus nanoparticles (NPs) that able to generate situ under radiation extended time. NPs porous silicon (PSi) was modified via nanostopper technique. technique exploited prepare PSi had hydrophobic pore walls (inner face), while the external surfaces (outer face) were hydrophilic. As consequence, when dispersed an aqueous solution, contained substantial amount air trapped their nanopores. specific experimental setup developed prove these nano seeds indeed acting as nuclei microbubble growth during radiation. Using setup, cavitation thresholds compared completely hydrophilic counterparts by detecting subharmonic signals microbubbles. These experiments and numerical simulations bubble dynamics demonstrated generated with radii 1.1 μm. Furthermore, detected conventional medical device. Long circulation time ensured grafting two different PEG polymers, did not affect adversely generation. findings represent important landmark development possess properties both diagnostics therapy.