Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release

• DOI: 10.1021/acsami.7b12297
• Publication Date: 2017-09-29T21:09:16Z
• Authors: Yongbeom Seo; Jiayu Leong; Jye Yng Teo; Jennifer W. Mitchell; Martha U. Gillette; Bumsoo Han; Jonghwi Lee; Hyunjoon Kong
• Keywords: PLGA; Biomolecule; Particle (ecology)

Overproduced reactive oxygen species (ROS) are closely related to various health problems including inflammation, infection, and cancer. Abnormally high ROS levels can cause serious oxidative damage biomolecules, cells, tissues. A series of nano- or microsized particles has been developed reduce the stress level by delivering antioxidant drugs. However, most systems often plagued slow molecular discharge, driven diffusion. Herein, this study demonstrates polymeric whose internal pressure increase upon exposure H2O2, one ROS, in turn, discharge antioxidants actively. The on-demand pressurized assembled simultaneously encapsulating water-dispersible manganese oxide (MnO2) nanosheets green tea derived epigallocatechin gallate (EGCG) molecules into a poly(lactic-co-glycolic acid) (PLGA) spherical shell. In presence MnO2 PLGA particle generate gas decomposing H2O2 pressure. release antioxidative EGCG actively and, protect vascular brain tissues from more effectively than without nanosheets. This responsive, self-pressurizing system would be useful deliver wide array cargos response oxidation level.