Degradable NIR-PTT Nanoagents with a Potential Cu@Cu2O@Polymer Structure

• DOI: 10.1021/acsami.7b15109
• Publication Date: 2018-01-23T10:21:40Z
• Authors: Yu-Wei Tai; Yi-Chun Chiu; Po-Ting Wu; Jiashing Yu; Yu-Cheng Chin; Shu-Pao Wu; Yu-Chun Chuang; Ho-Chen Hsieh; Ping-Shan Lai; Hsiu-Ping Yu; Mei-Yi Liao
• Keywords: HeLa

Cu@Cu2O@PSMA polymer nanoparticles (Cu@Cu2O@polymer NPs) with near-infrared (NIR) absorption were successfully synthesized in a single-step oxidation reaction of Cu@PSMA NPs at 100 °C for 20 min. The shape, structure, and optical properties the Cu@Cu2O@polymer tailorable by controlling parameters, example, using initial NP as template varying halide ion content, heating temperature, time. exhibited robust NIR between 650 710 nm possessed superior resistance water culture media. In vitro assays demonstrated low cytotoxicity to HeLa cells through an improved cell viability, high IC50, injury incidence from supernatant partly dissociated NPs, minor generation reactive oxygen species. More importantly, we that inorganic Cu-based nanocomposite [+0.34 V vs normal hydrogen electrode (NHE)] was degradable endogenous H2O2 (+1.78 NHE) environment. Cu ions detected urine mice, which illustrates possibility extraction after degradation particles. 'After treatment 660 light-emitting diode, photoablation 50 90% observed doses ppm, respectively. These results demonstrate NIR-functional moderate redox-active are potential next-generation photothermal therapy (PTT) nanoagents because combined features physiological environment, enabling delivery efficient PTT, possibly ability selectively harm cancer releasing under high-H2O2 and/or low-pH conditions, be extracted body biodegradation.