Zirconium-Based Nanoscale Metal–Organic Framework/Poly(ε-caprolactone) Mixed-Matrix Membranes as Effective Antimicrobials

• DOI: 10.1021/acsami.7b15826
• Publication Date: 2017-11-08T16:42:06Z
• Authors: Ming Liu; Lei Wang; Xiaohua Zheng; Zhigang Xie
• Keywords: Caprolactone; Matrix (chemical analysis)

Metal-organic framework (MOF)-polymer mixed-matrix membranes (MMMs) have shown their superior performance in gas separation. However, biological application has not been well-explored yet. Herein, a series of zirconium-based MOF MMMs with high loading and homogeneous composition prepared through facile drawdown coating process. Poly(ε-caprolactone) (PCL) selected as binder for its good biocompatibility biodegradability. Zr-MOF nanoparticles, UiO-66, MOF-525, utilized "filler" because chemical stability, safety, versatile functions. Both UiO-66/PCL MOF-525/PCL uniform appearance even at the highest 50 wt % UiO-66 30 respectively. The integrity pore structures within maintains well, which is evidenced by dye All obtained possess mechanical property. Upon irradiation, generate reactive oxygen species serve effective antibacterial photodynamic agents against Escherichia coli. This study offers an alternative system forming MOF/polymer represents first example exploiting hybrid applications.