Tumor Catalytic–Photothermal Therapy with Yolk–Shell Gold@Carbon Nanozymes

• DOI: 10.1021/acsami.7b17916
• Publication Date: 2018-01-17T20:15:32Z
• Authors: Lei Fan; Xiangdong Xu; Chunhua Zhu; Jie Han; Lizeng Gao; Juqun Xi; Rong Guo
• Keywords: Photothermal effect; Horseradish peroxidase

Nanozymes, as a new generation of artificial enzymes, offer great opportunities in biomedical engineering and disease treatment. Synergizing the multiple intrinsic functions nanozymes can improve their performance biological systems. Here, we report novel nanozyme with yolk-shell structure fabricated by combining single gold nanoparticle core porous hollow carbon shell nanospheres (Au@HCNs). Au@HCNs exhibited enzyme-like activities similar to horseradish peroxidase oxidase under an acidic environment, showing ability ROS generation. More importantly, production was significantly improved upon 808 nm light irradiation photothermal effect, which is often used for tumor therapy. Cellular animal studies further demonstrated that efficient destruction achieved through combination light-enhanced These results implied activity conversion be synergized treatment, providing proof-of-concept catalytic-photothermal therapy based on nanozymes.