Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma

• DOI: 10.1021/acsami.7b19716
• Publication Date: 2018-01-12T17:12:02Z
• Authors: Min Qian; Yilin Du; Shanshan Wang; Chengyi Li; Huiling Jiang; Wei Shi; Jian Chen; Yi Wang; Ernst Wagner; Rongqin Huang
• Keywords: Nanodot; Biocompatibility; Nanomaterials

Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system presents a great challenge for the current nanomaterial design. Herein, an situ solid-state transformation method was developed preparation multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm-sized HCCDs containing nanocore hydrophilic surface, which therefore simultaneously provide strong photoacoustic performances as well tunable fluorescence emission. In vitro vivo results demonstrate that novel have high water dispersity good biocompatibility, but potent tumor cell killing upon near-infrared irradiation. As demonstrated U87 glioma-bearing mice, specifically accumulate brain facilitate dual-modal imaging-guided PTT, with therapeutic antitumoral effects without any apparent damage to normal tissues.