Controlled Growth of N-Doped and Large Mesoporous Carbon Spheres with Adjustable Litchi-Like Surface and Particle Size as a Giant Guest Molecule Carrier

• DOI: 10.1021/acsami.8b02040
• Publication Date: 2018-06-01T18:37:16Z
• Authors: Wenquan Huang; Hui Xie; Yong Tian; Xiufang Wang
• Keywords: Particle (ecology); Carbon fibers

N-doped mesoporous carbon nanospheres (NMCNs) with tunable particle size, pore surface roughness, and inner cavity are extremely important for the future development of new carriers nanoencapsulation, high-performance giant molecule transport, cell uptake. However, constructing such a multifunctional material via simple method still remains great challenge. Herein, controlled growth technology was developed first time to synthesize NMCNs based on initial reaction temperature (IRT) solution polarity. In this strategy, IRT not only can adjust micelle aggregation obtain large mesopores but also make F127 more lyophobic prepare hollow spheres, which is breakthrough. Inspiringly, by varying polarity nonuniform nanoparticles, litchi-like rough obtained, could significantly improve uptake performance NMCNs. The current understanding nucleation mechanism further extended realized surface, provided interesting fundamental principle synthesis structure successfully reverse-replicated nanocasting tetraethylorthosilicate silica spheres (MSNs), revealing easy transformation between MSNs. Insulin as peptide drug cannot be directly administered orally. But it used oral preparation after being loaded into NMCNs, has never been reported before. Interestingly, results animal experiment showed an excellent in vivo hypoglycemic activity. This finding provides paradigm fabrication structurally well-defined promise carriers.