Nanosizing Noncrystalline and Porous Silica Material—Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery

• DOI: 10.1021/acsami.8b06275
• Publication Date: 2018-07-19T06:43:46Z
• Authors: Qian Guo; Zengyan Chang; Naveed Ullah Khan; Tongtong Miao; Xiufeng Ju; Huaxiang Feng; Lei Zhang; Zhenglong Sun; Hui Li; Liang Han
• Keywords: Targeted drug delivery

Opal shale, as a naturally occurring and noncrystalline silica material with porous structure, has the potential to be drug delivery carrier. In this study, we obtained opal shale nanoparticles (OS NPs) through techniques of ultrasonic emulsion differential centrifugation. The OS NPs exhibited markedly lower cytotoxicity than crystalline mesoporous nanoparticles. highly structure strong adsorbability endowed ability loading sustained release doxorubicin (DOX). DOX-loaded improved tumor cellular uptake antiproliferation compared free drug. Interestingly, possessed binding nuclear envelope, which can beneficial nucleus localization apoptosis inducing loaded DOX. We further demonstrated passive targeting ability, prolonged blood circulation, enhanced antitumor effect limited in vivo toxicity. Our results suggest that applied for delivery, may have significant influence on development silica-based system.