Lipid-Wrapped Upconversion Nanoconstruct/Photosensitizer Complex for Near-Infrared Light-Mediated Photodynamic Therapy

• DOI: 10.1021/acsami.8b07760
• Publication Date: 2018-11-30T20:05:16Z
• Authors: Pounraj Thanasekaran; Chih-Hang Chu; Sheng-Bo Wang; Kuan-Yu Chen; Hua-De Gao; Mandy M. Lee; Shih-Sheng Sun; Jui-Ping Li; Jiun-Yu Chen; Jen-Kun Chen; Yu-Hsu Chang; Hsien-Ming Lee
• Keywords: Photon Upconversion; Light energy; Visible spectrum

Photodynamic therapy (PDT) is a noninvasive medical technology that has been applied in cancer treatment where it accessible by direct or endoscope-assisted light irradiation. To lower phototoxicity and increase tissue penetration depth of light, great effort focused on developing new sensitizers can utilize red near-infrared (NIR) for the past decades. Lanthanide-doped upconversion nanoparticles (UCNPs) have unique property to transduce NIR excitation UV–vis emission efficiently. This allows some low-cost, low-toxicity, commercially available visible sensitizers, which originally are not suitable deep PDT, be activated reported extensively few years. However, issues still remain UCNP-assisted PDT platform such as colloidal stability, photosensitizer loading efficiency, accessibility targeting ligand installation, despite advances this direction. In study, we designed facile phospholipid-coated UCNP method generate highly colloidally stable nanoplatform effectively load series lipid layers. The stability singlet oxygen generation efficiency sensitizer-loaded lipid-coated were investigated. We also demonstrated enhanced cellular uptake tumor cell selectivity changing dopant. On basis evidence our results, lipid-complexed could serve an effective carrier light-mediated PDT.