Reactive Oxygen Species-Responsive Nanoparticles Based on PEGlated Prodrug for Targeted Treatment of Oral Tongue Squamous Cell Carcinoma by Combining Photodynamic Therapy and Chemotherapy

• DOI: 10.1021/acsami.8b08269
• Publication Date: 2018-08-14T14:21:51Z
• Authors: Shurui Shi; Lianyun Zhang; Mengqi Zhu; Guoyun Wan; Changyi Li; Juan Zhang; Yue Wang; Yinsong Wang
• Keywords: Hematoporphyrin

In this study, a reactive oxygen species (ROS)-responsive nanoparticle system was designed for combining photodynamic therapy (PDT) and chemotherapy oral tongue squamous cell carcinoma (OTSCC)-targeted treatment. A PEGlated prodrug (RPTD) of doxorubicin (DOX) via thioketal linkage cRGD peptide modification synthesized then used to prepare nanoparticles encapsulating photosensitizer hematoporphyrin (HP). Thus, the obtained HP-loaded RPTD (RPTD/HP) had regular spherical shape small size, approximately 180 nm. The RPTD/HP showed remarkable PDT efficiency successfully induced ROS generation upon laser irradiation both in vitro vivo. DOX exhibited significant ROS-responsive release property from because rupture linker. OTSCC cells, were efficiently internalized potent effects on growth inhibition apoptosis induction after irradiation. tumor-bearing mice, displayed excellent tumor-targeting ability notably suppressed tumor through multiple mechanisms local Taken together, we supplied novel therapeutic nanosystem treatment chemotherapy.