Self-Adapting Hydrogel to Improve the Therapeutic Effect in Wound-Healing

• DOI: 10.1021/acsami.8b08874
• Publication Date: 2018-07-16T09:34:41Z
• Authors: Yongsan Li; Xing Wang; Ya-nan Fu; Yen Wei; Lingyun Zhao; Lei Tao
• Keywords: Chitosan; Drug Carriers; Wound Healing; Animals; Hydrogels; 02 engineering and technology; 0210 nano-technology; Hydrogel, Polyethylene Glycol Dimethacrylate; Rats

Smart materials that can respond to multistimuli have been broadly studied. However, the smart materials that can spontaneously answer the ever-changing inner environment of living bodies have not been reported. Here, we report a strategy based on the dynamic chemistry to develop possible self-adapting solid materials that can automatically change shape without external stimuli, as organisms do. The self-adapting property of a chitosan-based self-healing hydrogel has been rediscovered since its dynamic Schiff-base network confers the unique mobility to that solid gel. As a result, the hydrogel can move slowly, like an octopus climbing through a narrow channel, only following the natural forces of surface tension and gravity. The fascinating self-adapting feature enables this hydrogel as an excellent drug carrier for the in vivo wound treatment. In a healing process of the rat-liver laceration, this self-adapting hydrogel demonstrated remarkable superiority over traditional drug delivery methods, suggesting the great potential of this self-adapting hydrogel as a promising new material for biomedical applications. We believe the current research revealed a possible strategy to achieve self-adapting materials and may pave the way toward the further development, study, and application of new-generation smart materials.