Self-Adapting Hydrogel to Improve the Therapeutic Effect in Wound-Healing

• DOI: 10.1021/acsami.8b08874
• Publication Date: 2018-07-16T09:34:41Z
• Authors: Yongsan Li; Xing Wang; Ya-nan Fu; Yen Wei; Lingyun Zhao; Lei Tao
• Keywords: Smart material; Stepping stone

Smart materials that can respond to multistimuli have been broadly studied. However, the smart spontaneously answer ever-changing inner environment of living bodies not reported. Here, we report a strategy based on dynamic chemistry develop possible self-adapting solid automatically change shape without external stimuli, as organisms do. The property chitosan-based self-healing hydrogel has rediscovered since its Schiff-base network confers unique mobility gel. As result, move slowly, like an octopus climbing through narrow channel, only following natural forces surface tension and gravity. fascinating feature enables this excellent drug carrier for in vivo wound treatment. In healing process rat-liver laceration, demonstrated remarkable superiority over traditional delivery methods, suggesting great potential promising new material biomedical applications. We believe current research revealed achieve may pave way toward further development, study, application new-generation materials.