Overcoming Chemoresistance in Cancer via Combined MicroRNA Therapeutics with Anticancer Drugs Using Multifunctional Magnetic Core–Shell Nanoparticles

• DOI: 10.1021/acsami.8b09086
• Publication Date: 2018-07-20T17:46:47Z
• Authors: Perry T. Yin; Thanapat Pongkulapa; Hyeon-Yeol Cho; Jiyou Han; Nicholas J. Pasquale; Hudifah Rabie; Jong-Hoon Kim; Jeong-Woo Choi; Ki-Bum Lee
• Keywords: Magnetics; MicroRNAs; Drug Delivery Systems; Doxorubicin; Drug Resistance, Neoplasm; Neoplasms; Humans; 02 engineering and technology; Magnetite Nanoparticles; 0210 nano-technology; Magnetic Resonance Imaging; 3. Good health

In this study, we report the use of a multifunctional magnetic core–shell nanoparticle (MCNP), composed highly zinc-doped iron oxide (ZnFe2O4) core and biocompatible mesoporous silica (mSi) shell, for simultaneous delivery let-7a microRNA (miRNA) anticancer drugs (e.g., doxorubicin) to overcome chemoresistance in breast cancer. Owing ability repress DNA repair mechanisms BRCA1 BRCA2) downregulate drug efflux pumps ABCG2), could sensitize chemoresistant cancer cells (MDA-MB-231) subsequent doxorubicin chemotherapy both vitro vivo. Moreover, multifunctionality our MCNPs allows monitoring vivo via resonance imaging. short, have developed MCNP-based therapeutic approach provide an attractive method with which enhance not only deliver combined miRNA therapeutics small-molecule selective effective manner but also enhanced treatment combination replacement therapy using single nanoplatform.