Tracing Boron with Fluorescence and Positron Emission Tomography Imaging of Boronated Porphyrin Nanocomplex for Imaging-Guided Boron Neutron Capture Therapy

• DOI: 10.1021/acsami.8b14682
• Publication Date: 2018-11-19T14:06:32Z
• Authors: Yaxin Shi; Jiyuan Li; Zizhu Zhang; Dongban Duan; Zhengchu Zhang; Hui Liu; Tong Liu; Zhibo Liu
• Keywords: Neutron capture; Neutron Imaging; Tracing

Boron neutron capture therapy (BNCT) induces high-energy radiation within cancer cells while avoiding damage to normal without uptake of BNCT drugs, which is holding great promise provide excellent control over locally invasive malignant tumors. However, lack quantitative imaging technique determine local boron concentration has been a challenge for nuclear physicians apply accurate irradiation during the treatment, key factor that limited BNCT's application in clinics. To meet this challenge, study describes coating boronated porphyrins with biocompatible poly(lactide-co-glycolide)–monomethoxy-poly(polyethylene-glycol) (PLGA–mPEG) micelle selective tumor accumulation and reduced toxicity comparing previously reported porphyrin drugs. Fluorescence positron emission tomography (PET) were performed, unveiling potential properties nanocomplex (BPN) locate region tissue-localized facilitates treatment planning. By studying pharmacokinetics BPN Cu-64 PET imaging, plan was adjusted from single bolus injection multiple times injections smaller doses. As expected, high (125.17 ± 13.54 ppm) achieved an extraordinarily tissue ratio: tumors liver, muscle, fat, blood 3.24 0.22, 61.46 20.26, 31.55 10.30, 33.85 5.73, respectively. At last, showed almost complete suppression, demonstrating holds being efficient delivery agent imaging-guided BNCT.