Laser-Induced Transformable BiS@HSA/DTX Multiple Nanorods for Photoacoustic/Computed Tomography Dual-Modal Imaging Guided Photothermal/Chemo Combinatorial Anticancer Therapy

• DOI: 10.1021/acsami.8b16395
• Publication Date: 2018-11-08T12:26:26Z
• Authors: Weisheng Guo; Jing Chen; Lu Liu; Ahmed Shaker Eltahan; Nicola Rosato; Jing Yu; Dongliang Wang; Jingqi Chen; Massimo Bottini; Xing-Jie Liang
• Keywords: Nanorod; Human serum albumin

Suboptimal intratumor accumulation and poorly controllable release of encapsulated drugs remain unresolved challenges hampering further advancement nanomedicines in cancer therapy. Herein, we conceived near-infrared (NIR) laser-triggered transformable BiS@HSA/DTX multiple nanorods (mNRs), which were made small bundles bismuth sulfide (BiS NRs) coated with docetaxel (DTX)-inlaid human serum albumin (HSA). The mNRs had a lateral size approximately 100 nm efficiently accumulated the tumor microenvironment upon systemic administration tumor-bearing nude mice. NIR laser irradiation area caused rapid disassembly into individual HSA-coated BiS (BiS@HSA iNRs) triggered DTX from HSA corona, due to local temperature increase generated by NRs via photothermal effect. laser-induced transformation BiS@HSA iNRs facilitated their penetration increased retention time tumor. spatiotemporal delivery behavior could be monitored photoacoustic/computed tomography dual-modal imaging vivo. Furthermore, because excellent conversion properties mNRs, efficient combinatorial therapy was achieved concurrent hyperthermia chemotherapy mice treated irradiation.