Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy

• DOI: 10.1021/acsami.8b18425
• Publication Date: 2018-12-18T12:05:26Z
• Authors: Lijun Yang; Congrou Zhang; Chunhua Ren; Jinjian Liu; Yumin Zhang; Jing Wang; Fan Huang; Lei Zhang; Jianfeng Liu
• Keywords: Chlorambucil; Biocompatibility; Self-assembling peptide; Cancer Therapy; Targeted drug delivery

Supramolecular hydrogels of self-assembling peptide–drug conjugates have been considered as effective self-delivery drug systems for cancer therapy in recent years. Here, a novel peptide-based supramolecular hydrogel was developed by simultaneously conjugating small-molecule chlorambucil (CRB) and peptide tyroservatide (YSV) to the peptide. The resulting with nanofiber structure showed enhanced stability against proteinase K degradation an improved cellular uptake performance comparison free molecules. As consequence, it exhibited antitumor efficiency both vitro vivo favorable biocompatibility. This biocompatible system could not only significantly improve delivery drugs but also adequately synergize effect CRB YSV, inspiring design new strategies combination therapy.