Robust Induced Presynapse on Artificial Substrates as a Neural Interfacing Method

• DOI: 10.1021/acsami.8b20405
• Publication Date: 2019-02-01T22:56:40Z
• Authors: Joohee Jeon; Min-Ah Oh; Wonkyung Cho; Sun-Heui Yoon; Ji Yong Kim; Taek Dong Chung
• Keywords: Interfacing; Neural cell; Biological neural network; Robustness

Over the recent years, development of neural interface systems has stuck to using electrical cues stimulate neurons and read out signals, although relay signals via chemical release recognition at synapses. In addition, conventional interfaces are vulnerable cell migration glial encapsulation due absence connection anchoring neuron into device unlike synapses, which firmly sustained by protein bonding. To close this discrepancy, we conducted an intensive investigation induced synapse employing engineered synaptic proteins from a perspective. The strong potential differentiation as emerging interfacing technique is demonstrated exploring its structural features, kinetics, robustness, scalability brain tissue. We show that exocytosis kinetics synapses similar endogenous Moreover, remarkable stability, despite growth. synapse-inducing broad applications cultured hippocampal cortex tissues suggests promising method integrate circuits with digital elements.