Radiofrequency-Sensitive Longitudinal Relaxation Tuning Strategy Enabling the Visualization of Radiofrequency Ablation Intensified by Magnetic Composite

• DOI: 10.1021/acsami.9b02401
• Publication Date: 2019-03-07T15:59:54Z
• Authors: Yan Fang; Hong-Yan Li; Hao-Hao Yin; Shi-Hao Xu; Wei-Wei Ren; Shi-Si Ding; Wei-Zhong Tang; Li-Hua Xiang; Rong Wu; Xin Guan; Kun Zhang
• Keywords: Radiofrequency Ablation; Radio Waves; Transplantation, Heterologous; Contrast Media; Mice, Nude; 02 engineering and technology; Ferric Compounds; Magnetic Resonance Imaging; 01 natural sciences; 0104 chemical sciences; Menthol; Mice; Microscopy, Electron, Transmission; Cell Line, Tumor; Neoplasms; Animals; Humans; Magnetite Nanoparticles; 0210 nano-technology; Hydrophobic and Hydrophilic Interactions

As a minimally invasive heat source, radiofrequency (RF) ablation still encounters potential damages to the surrounding normal tissues because of heat diffusion, high power, and long time. With a comprehensive understanding of the current state of the art on RF ablation, a magnetic composite using porous hollow iron oxide nanoparticles (HIONs) as carriers to load dl-menthol (DLM) has been engineered. This composite involves two protocols for enhancing RF ablation, that is, HION-mediated magnetothermal conversion in RF field and RF solidoid vaporation (RSV)-augmented inertial cavitation, respectively. A combined effect based on two protocols is found to improve energy transformation, and further, along with hydrophobic DLM-impeded heat diffusion, improve the energy utilization efficiency and significantly facilitate ex vivo and in vivo RF ablation. More significantly, in vitro and in vivo RSV processes and RSV-augmented inertial cavitation for RF ablation can be monitored by T1-weighted magnetic resonance imaging (MRI) via an RF-sensitive longitudinal relaxation tuning strategy because the RSV process can deplete DLM and make HION carriers permeable to water molecules, consequently improving the longitudinal relaxation rate of HIONs and enhancing T1-weighted MRI. Therefore, this RF-sensitive magnetic composite holds a great potential in lowering the power and time of RF ablation and improving its therapeutic safety.