Protein Shell-Encapsulated Pt Clusters as Continuous O2-Supplied Biocoats for Photodynamic Therapy in Hypoxic Cancer Cells

• DOI: 10.1021/acsami.9b02484
• Publication Date: 2019-04-22T10:55:38Z
• Authors: Yahang Li; Xiaoxia Jian; Shanshan Zhou; Yongxin Lu; Chenxi Zhao; Zhida Gao; Yan-Yan Song
• Keywords: Nanoclusters; Nanocarriers; Biocompatibility; Bovine serum albumin; Nanocapsules; Tumor Hypoxia

As a highly oxygen-dependent process, the effect of photodynamic therapy is often obstructed by premature leakage photosensitizers and lack oxygen in hypoxic cancer cells. To overcome these limitations, this study designs bovine serum albumin protein (BSA)-encapsulated Pt nanoclusters (PtBSA) as O2-supplied biocoats further incorporates them with mesoporous silica nanospheres to develop intelligent nanoaggregates for achieving improved therapeutic outcomes against tumors. The large number amino groups on BSA can provide sufficient functional anchor tumor targeting agents thus enhance selective cellular uptake efficiency. Owing outstanding biocompatibility features state-of-the-art catalytic activity nanoclusters, nanocomposites have lower dark cytotoxicity, O2 continuously evolves via decomposition H2O2 microenvironment. Both vivo vitro experiments indicate that resulting effectively relieve conditions, specifically induce necrotic cell apoptosis, remarkably hinder growth. Our results illuminate great potential BSA-encapsulated versatile designing nanocarriers hypoxic-resistant therapy.