Novel Cellulose–Halloysite Hemostatic Nanocomposite Fibers with a Dramatic Reduction in Human Plasma Coagulation Time

• DOI: 10.1021/acsami.9b04615
• Publication Date: 2019-04-12T09:34:56Z
• Authors: Ranodhi N. Udangawa; Paiyz Esmat Mikael; Chiara Mancinelli; Caitlyn Chapman; Charles F. Willard; Trevor John Simmons; Robert J. Linhardt
• Keywords: Halloysite; Cellulose fiber

High-performance cellulose–halloysite hemostatic nanocomposite fibers (CHNFs) are fabricated using a one-step wet–wet electrospinning process and evaluated for human plasma coagulation by activated partial thromboplastin time. These novel biocompatible CHNFs exhibit 2.4 times faster time compared with the industry gold standard QuikClot Combat Gauze (QCG). The have superior antileaching property of clay 3 higher post-wetting clotting activity to QCG. also coagulate whole blood 1.3 than QCG retain twice performance after washing. Halloysite is more effective in commercial kaolin clay. physical thermal properties were scanning electron microscopy, energy-dispersive X-ray spectroscopy, diffraction, Brunauer–Emmett–Teller surface area analysis, thermogravimetric analysis. show 7-fold greater loading their small average diameter 450 ± 260 nm affords specific (33.6 m2 g–1) larger 12.6 0.9 μm 1.6 g–1. shown be noncytotoxic primary fibroblasts proliferated on composite material. drastic reduction makes this potential lifesaving material victims rapid loss such as military personnel patients undergoing major surgical procedures or aid treatment unexpected bleeding episodes suffering from hereditary disorders. Since person can die within minutes heavy bleeding, every second counts stopping traumatic hemorrhaging.