Rational Design of BODIPY-Diketopyrrolopyrrole Conjugated Polymers for Photothermal Tumor Ablation

• DOI: 10.1021/acsami.9b10713
• Publication Date: 2019-08-21T12:39:46Z
• Authors: Wei Zhang; Wenhai Lin; Chaonan Li; Shi Liu; Xiuli Hu; Zhigang Xie
• Keywords: Boron Compounds; Polymers; Hyperthermia, Induced; Ketones; Phototherapy; 01 natural sciences; Tumor Burden; 0104 chemical sciences; 3. Good health; Mice; Neoplasms; Animals; Humans; Nanoparticles; Pyrroles; Density Functional Theory; HeLa Cells

Conjugated polymers (CPs) have drawn growing attention in cancer phototherapy and imaging due to their large extinction coefficients, robust photostability, and good biocompatibility. Herein, we propose a new type of photothermal therapy materials on the basis of BODIPY-diketopyrrolopyrrole CPs, where the number of methyl substituents at the β and β' positions on BODIPYs is variable, allowing us to investigate the interplay between the structure of the monomers and the related properties of CPs. Combining the experimental data with theoretical calculations, we concluded that with the decrease of the number of methyl moieties on the β and β' positions of BODIPY, the polymerization degree and the solubility of the obtained CPs improved and the polymeric spatial planarization and degrees of conjugation increased, inducing the bathochromic shift of absorption, which resulted in the absorption spectra getting closer to the near-infrared region and more conducive to the application of the conjugated polymers in vivo. Afterward, the CP nanoparticles were constructed and their photothermal activity in cancer therapy was validated by a series of in vitro and in vivo experiments. In this paper, we provide a new way to manipulate properties of CPs with great potential in photothermal therapy through structural engineering.