Alkaline Earth Metal–Organic Frameworks with Tailorable Ion Release: A Path for Supporting Biomineralization

• DOI: 10.1021/acsami.9b11004
• Publication Date: 2019-08-15T15:09:57Z
• Authors: Maria A. Matlinska; Michelle Ha; Bryden Hughton; Anton O. Oliynyk; Abishek K. Iyer; Guy M. Bernard; Gareth Lambkin; Mason C. Lawrence; Michael J. Katz; Arthur Mar; Vladimir K. Micha...
• Keywords: Alkaline earth metal

An innovative application of metal–organic frameworks (MOFs) is in biomedical materials. To treat bone demineralization, which a hallmark osteoporosis, biocompatible MOFs (bioMOFs) have been proposed various components, such as alkaline-earth cations and bisphosphonate molecules, can be delivered to maintain normal density. Multicomponent bioMOFs that release several components simultaneously at controlled rate thus offer an attractive solution. We report two new bioMOFs, comprising strontium calcium ions linked by p-xylylenebisphosphonate molecules these three display no cytotoxic effects on human osteosarcoma cells. Varying the Sr2+/Ca2+ ratio causes dissolving into simulated body fluid unique; along with ability adsorb proteins, this property crucial for future efforts drug-release control promotion mineral formation. The one-pot synthesis demonstrates utility MOF design strategies.